García Márquez had his own conception of magical realism and where it came from (more on that later), but sometimes what he thought was imagination turned out to be something real. Early in One Hundred Years of Solitude, a plague of insomnia afflicts Macondo. Villagers begin forgetting the words for things and concepts; protagonist José Arcadio Buendía even meticulously labels everyday objects around town. This cognitive impairment was actually described in medical literature for the first time in 1975, eight years after the book’s initial release. It’s called semantic dementia, and García Márquez accurately describes the effects of certain kinds of degeneration in the brain’s frontal and temporal lobes.
Mental Floss, Jan. 22, 2016